Introduction

Letrozole is a medication primarily used in the treatment of hormone-responsive breast cancer in postmenopausal women. Its primary function is to reduce estrogen levels, which can promote the growth of certain types of breast tumors. But for many, the question remains: letrozole what is and how does it work?

What Is Letrozole?

Definition and Overview

Letrozole is classified Letrozol Teva Filmtabletten 2.5mg 100 as an aromatase inhibitor. It works by blocking the enzyme aromatase, which is responsible for converting androgens into estrogens in the body. By inhibiting this enzyme, letrozole significantly lowers estrogen levels, effectively starving hormone-dependent cancer cells of the estrogen they need to grow.

Uses of Letrozole What Is

Primary Medical Uses

• Breast cancer treatment in postmenopausal women
• Off-label use for fertility treatments and ovulation induction in women with polycystic ovary syndrome (PCOS)

In oncology, letrozole has become a cornerstone therapy for estrogen receptor-positive breast cancers. Its role in fertility treatments is also gaining attention due to its ability to induce ovulation with fewer side effects compared to other medications like clomiphene citrate.

How Does Letrozole Work?

Mechanism of Action

The drug inhibits the aromatase enzyme, which catalyzes the conversion of androgens (like testosterone) into estrogens (like estradiol). By decreasing estrogen synthesis, letrozole reduces the stimulation of estrogen-dependent tumor growth. This suppression helps slow or halt the progression of hormone-sensitive breast cancers.

Administration and Dosage

Guidelines for Use

Letrozole what is varies based on the condition being treated. For breast cancer, the typical dosage is 2.5 mg taken once daily for a period determined by the oncologist. When used for fertility purposes, the dosage may be lower and administered over a specific number of days during the menstrual cycle.

Potential Side Effects

While effective, letrozole can cause side effects such as hot flashes, fatigue, joint pain, and bone thinning. Patients should discuss risks and benefits thoroughly with their healthcare provider before starting treatment.

Conclusion

Understanding letrozole what is involves recognizing its role as a potent aromatase inhibitor used primarily in breast cancer therapy and fertility treatments. Its ability to regulate estrogen levels makes it a valuable tool in managing hormone-driven conditions, but careful medical supervision is essential to ensure safety and effectiveness.